2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole

Base Information

Chemical Name:2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole
CAS No.:105431-73-0
Molecular Formula:C₂₀H₁₆N₂O
Molecular Weight:300.36
Hs Code.:
DSSTox Substance ID:DTXSID801196264
Nikkaji Number:J573.644G
ChEMBL ID:CHEMBL99064

Synonyms:CHEMBL99064;SCHEMBL4599210;DTXSID801196264;1,3-Dihydro-1-phenyl-3-(4-pyridinylmethyl)-2H-indol-2-one;2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole;105431-73-0

Suppliers and Price of 2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:300.126263138
Heavy Atom Count:23
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)CC4=CC=NC=C4

Technology Process of 2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole

There total 8 articles about 2,3-Dihydro-1-phenyl-3-(4-pyridylmethyl)-2-oxo-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

: 1,3-dihydro-3-(4-pyridinylmethylene)-1-phenyl-2H-indole-2-one

: 105431-73-0
1,3-dihydro-1-phenyl-3-(4-pyridinylmethyl)-2H-indol-2-one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; a) RT, 24 h, b) reflux, 2 h;
DOI:10.1021/jm00072a009

Reference yield:

: 154479-62-6
3-(4-pyridinylmethylene)-1-phenyl-2H-indolin-2-one

: 105431-73-0
1,3-dihydro-1-phenyl-3-(4-pyridinylmethyl)-2H-indol-2-one

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In methanol; at 35 ℃;
DOI:10.1080/00397919308011258

Reference yield:

: 723-89-7
1-phenyl-indole-2,3-dione

: 105431-73-0
1,3-dihydro-1-phenyl-3-(4-pyridinylmethyl)-2H-indol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: AcOH / 125 - 130 °C

2: acetic acid / 2 h / 120 - 125 °C

3: propan-2-ol / 60 - 80 °C

4: 50percent aq. NaOH, NaBH₄ / methanol / 35 °C

With sodium hydroxide; sodium tetrahydroborate; acetic acid; In methanol; acetic acid; isopropyl alcohol;
DOI:10.1080/00397919308011258