Technology Process of [4,5-2H2]-(4S,5R)-2,2-dimethyl-5-(triphenylsilyl)-1,3-dioxolane-4-carbaldehyde
There total 5 articles about [4,5-2H2]-(4S,5R)-2,2-dimethyl-5-(triphenylsilyl)-1,3-dioxolane-4-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3R)-3-(triphenylsilyl)<2,3-(2)H2>oxiranecarboxaldehyde; acetone;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Molecular sieve;
With
tin(IV) chloride;
In
dichloromethane;
at -78 - -40 ℃;
for 168.5h;
regioselective reaction;
DOI:10.1002/chem.201400296
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium deuteride
2.1: C11H26O5Ti; L-(+)-diisopropyl tartrate / tert-butyl alcohol
3.1: sulfur trioxide pyridine complex / dimethyl sulfoxide
4.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve
4.2: 168.5 h / -78 - -40 °C
With
lithium aluminium deuteride; L-(+)-diisopropyl tartrate; C11H26O5Ti; sulfur trioxide pyridine complex;
In
dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;
2.1: |Sharpless Asymmetric Epoxidation / 3.1: |Parikh-Doering Oxidation;
DOI:10.1002/chem.201400296
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: C11H26O5Ti; L-(+)-diisopropyl tartrate / tert-butyl alcohol
2.1: sulfur trioxide pyridine complex / dimethyl sulfoxide
3.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve
3.2: 168.5 h / -78 - -40 °C
With
L-(+)-diisopropyl tartrate; C11H26O5Ti; sulfur trioxide pyridine complex;
In
dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;
1.1: |Sharpless Asymmetric Epoxidation / 2.1: |Parikh-Doering Oxidation;
DOI:10.1002/chem.201400296
