1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

Base Information

Chemical Name:1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride
CAS No.:1345614-78-9
Molecular Formula:C₄₀H₄₀F₆N₃O₇S₂*Cl
Molecular Weight:888.349
Hs Code.:

Synonyms:1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

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Chemical Property of 1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

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Technology Process of 1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

There total 10 articles about 1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1345614-76-7
3-[7-(tert-butyldimethylsilanyloxy)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

: 1345614-67-6
3-(7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

: 1345614-78-9
1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

Guidance literature:: With hydrogenchloride; In ethanol; water; at 80 ℃; for 1.5h;
DOI:10.1021/ol202619f

Reference yield:

: 1345614-60-9
3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

: 1345614-78-9
1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / acetone / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 65 °C

3: sulfuric acid / methanol; water / 1 h / 20 °C

4: hydrogenchloride / ethanol; water / 1.5 h / 80 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; sodium iodide; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol202619f

Reference yield:

: 22246-18-0
7-hydroxy-3,4-dihydro-2-(1H)-quinolinone

: 1345614-78-9
1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / Reflux

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 65 °C

4: hydrogenchloride / ethanol; water / 1.5 h / 80 °C

With 1H-imidazole; hydrogenchloride; borane-THF; potassium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol202619f