3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Base Information

• Chemical Name: 3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester
• CAS No.: 1345614-60-9
• Molecular Formula: C₁₁H₁₂ClF₃O₃S
• Molecular Weight: 316.729
• Mol file: 1345614-60-9.mol

Synonyms:3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Chemical Property of 3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

There total 1 articles about 3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-chloro-n-propanesulfonyl chloride (1633-82-5) + 1-phenyl-2,2,2-trifluoromethylethanol (340-04-5,340-05-6) → 3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-60-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/ol202619f

Reference yield: 95.0%

3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-60-9) → 3-iodopropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-62-1)

Guidance literature:

With sodium iodide; In acetone; Reflux;

DOI:10.1021/ol202619f

Reference yield:

3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-60-9) → 1,11-bis[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene chloride (1345614-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium iodide / acetone / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 65 °C

3: sulfuric acid / methanol; water / 1 h / 20 °C

4: hydrogenchloride / ethanol; water / 1.5 h / 80 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; sodium iodide; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol202619f

upstream raw materials:

3-chloro-n-propanesulfonyl chloride

1-phenyl-2,2,2-trifluoromethylethanol

Downstream raw materials:

3-iodopropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

3-(7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate