tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

Base Information

Chemical Name:tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate
CAS No.:1438081-00-5
Molecular Formula:C₃₀H₃₇ClFN₅O₄
Molecular Weight:586.106
Hs Code.:

Synonyms:tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

There total 11 articles about tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1438080-94-4
tert-butyl 6-(3-chloropropyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1438081-00-5
tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438081-00-5
tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 5 h / 88 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1438081-00-5
tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[2,3-c] pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 3 h / 0 - 20 °C

2: acetic acid; hydrogen; Adam’s catalyst / ethanol / 15001.5 Torr

3: potassium carbonate / acetone / 7 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C

With Adam’s catalyst; hydrogen; potassium carbonate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; acetone;