2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

Base Information

Chemical Name:2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone
CAS No.:189956-01-2
Molecular Formula:C₁₂H₁₃F₃O₄S
Molecular Weight:310.294
Hs Code.:

Synonyms:2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

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Chemical Property of 2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

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Technology Process of 2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

There total 9 articles about 2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 209518-82-1
(1R,2R)-4,4,4-Trifluoro-1-(4-methanesulfonyl-phenyl)-2-methyl-butane-1,2-diol

: 189956-01-2
2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(98)00735-7

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 189956-01-2
2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / MgBr₂, NEt₃ / tetrahydrofuran

2: 97 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3: diisopropylethylamine / dimethylformamide

4: KF, CuI, diisopropylethylamine / dimethylformamide / 1 h / 90 °C

5: K₃OsO₄, (DHQD)2PHAL, K₂CO₃, I₂ / H₂O; 2-methyl-propan-2-ol / 22 h / 18 - 20 °C

6: 94 percent / 1.) DMSO, ClCOCOCl; 2.) NEt₃ / CH₂Cl₂ / 0.5 h / -78 °C

With potassium fluoride; potassium osmate(VI); copper(l) iodide; oxalyl dichloride; iodine; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium bromide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00735-7

Reference yield:

: 209518-73-0
(2E) Ethyl 2-methyl-3-(4-methylthiophenyl)propenate

: 189956-01-2
2-(R)-hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)-4,4,4-trifluoro-1-butanone

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: diisopropylethylamine / dimethylformamide

3: KF, CuI, diisopropylethylamine / dimethylformamide / 1 h / 90 °C

4: K₃OsO₄, (DHQD)2PHAL, K₂CO₃, I₂ / H₂O; 2-methyl-propan-2-ol / 22 h / 18 - 20 °C

5: 94 percent / 1.) DMSO, ClCOCOCl; 2.) NEt₃ / CH₂Cl₂ / 0.5 h / -78 °C

With potassium fluoride; potassium osmate(VI); copper(l) iodide; oxalyl dichloride; iodine; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00735-7