Mfx6DY4eeb

Base Information

Chemical Name:Mfx6DY4eeb
CAS No.:189955-09-7
Molecular Formula:C₂₀H₁₅F₅O₅S
Molecular Weight:462.394
Hs Code.:
UNII:MFX6DY4EEB
Nikkaji Number:J971.555J

Synonyms:MFX6DY4EEB;L-784512;L784512;(5R)-3-(3,4-Difluorophenoxy)-5-methyl-4-(4-(methylsulfonyl)phenyl)-5-(2,2,2-trifluoroethyl)-2(5H)-furanone;2(5H)-Furanone, 3-(3,4-difluorophenoxy)-5-methyl-4-(4-(methylsulfonyl)phenyl)-5-(2,2,2-trifluoroethyl)-, (5R)-;2(5H)-Furanone, 3-(3,4-difluorophenoxy)-5-methyl-4-(4-(methylsulfonyl)phenyl)-5-(2,2,2-trifluoroethyl)-, (R)-;3-(3,4-Difluorophenoxy)-5(R)-methyl-4-(4-(methylsulfonyl) phenyl)-5-(2,2,2-trifluoroethyl)furan-2(5H)-one;UNII-MFX6DY4EEB;SCHEMBL5208009;LHPVVAWHVOREIY-LJQANCHMSA-N;189955-09-7;548772-57-2

Suppliers and Price of Mfx6DY4eeb

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of Mfx6DY4eeb

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:462.05603556
Heavy Atom Count:31
Complexity:826

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C(=C(C(=O)O1)OC2=CC(=C(C=C2)F)F)C3=CC=C(C=C3)S(=O)(=O)C)CC(F)(F)F
Isomeric SMILES:C[C@]1(C(=C(C(=O)O1)OC2=CC(=C(C=C2)F)F)C3=CC=C(C=C3)S(=O)(=O)C)CC(F)(F)F

Technology Process of Mfx6DY4eeb

There total 15 articles about Mfx6DY4eeb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189956-02-3
(2R)-2-Chloroacetoxy-2-methyl-1-(4-methylsulfonyl)-phenyl-4,4,4-trifluoro-butan-1-one

: 2713-33-9
3,4-difluorophenol

: 189955-09-7
(5R)-3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl) phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one

Guidance literature:

Reference yield:

: 209518-73-0
(2E) Ethyl 2-methyl-3-(4-methylthiophenyl)propenate

: 189955-09-7
(5R)-3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl) phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: diisopropylethylamine / dimethylformamide

3: KF, CuI, diisopropylethylamine / dimethylformamide / 1 h / 90 °C

4: K₃OsO₄, (DHQD)2PHAL, K₂CO₃, I₂ / H₂O; 2-methyl-propan-2-ol / 22 h / 18 - 20 °C

5: 94 percent / 1.) DMSO, ClCOCOCl; 2.) NEt₃ / CH₂Cl₂ / 0.5 h / -78 °C

6: CMC, DMAP / CH₂Cl₂ / 4 h

7: DBU, isopropyl trifluoroacetate / CH₂Cl₂

With dmap; potassium fluoride; potassium osmate(VI); copper(l) iodide; oxalyl dichloride; isopropyl Trifluoroacetate; iodine; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00735-7

Reference yield:

: 209518-74-1
ethyl (E)-2-methyl-3-(4-(methylsulfonyl)phenyl)acrylate

: 189955-09-7
(5R)-3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl) phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: diisopropylethylamine / dimethylformamide

3: KF, CuI, diisopropylethylamine / dimethylformamide / 1 h / 90 °C

4: 90 percent / K₃OsO₄, (DHQD)2PHAL, K₂CO₃, I₂ / H₂O; 2-methyl-propan-2-ol / 6 h / 18 - 20 °C

5: 94 percent / 1.) DMSO, ClCOCOCl; 2.) NEt₃ / CH₂Cl₂ / 0.5 h / -78 °C

6: CMC, DMAP / CH₂Cl₂ / 4 h

7: DBU, isopropyl trifluoroacetate / CH₂Cl₂

With dmap; potassium fluoride; potassium osmate(VI); copper(l) iodide; oxalyl dichloride; isopropyl Trifluoroacetate; iodine; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00735-7