(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

Base Information

Chemical Name:(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate
CAS No.:113507-08-7
Molecular Formula:C₂₇H₄₂O₄SSi
Molecular Weight:490.78
Hs Code.:

Synonyms:(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

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Technology Process of (2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

There total 14 articles about (2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 124-63-0
methanesulfonyl chloride

: 113490-14-5
(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyloctan-1-ol

: 113507-08-7
(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jo00244a017

Reference yield:

: 104486-22-8
Propionic acid (S)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-allyl ester

: 113507-08-7
(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

2: H₂ / PtO₂ / ethanol / 760 Torr

3: LDA / tetrahydrofuran

4: Hunig's base, DMAP / CH₂Cl₂ / 0 - 20 °C

6: pyridine / CH₂Cl₂

With pyridine; dmap; hydrogen; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00372a051

Reference yield:

: 113564-18-4
(2S,3S)-2-methyl-4-pentene-1,3-diol

: 113507-08-7
(2S,6R)-8-<(tert-butyldiphenylsilyl)oxy>-2,6-dimethyl-1-octyl methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N, DMAP / CH₂Cl₂

2: pyridine / CH₂Cl₂

4: H₂ / PtO₂ / ethanol / 760 Torr

5: LDA / tetrahydrofuran

6: Hunig's base, DMAP / CH₂Cl₂ / 0 - 20 °C

8: pyridine / CH₂Cl₂

With pyridine; dmap; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00372a051