2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Base Information

Chemical Name:2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone
CAS No.:1312777-17-5
Molecular Formula:C₁₉H₂₃NO₁₁
Molecular Weight:445.36
Hs Code.:

Synonyms:2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Suppliers and Price of 2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

There total 5 articles about 2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1312777-32-4
N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 1312777-17-5
2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Guidance literature:: N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid; With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

benzyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 23 ℃; for 1.25h;
DOI:10.1016/j.tetasy.2011.02.012

Reference yield:

: 1312776-91-2
N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

: 1312777-17-5
2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 22 °C

2.1: sodium hydroxide / water / 0.5 h / 40 °C

2.2: Dowex_.(R). 50WX₈ (H⁺) resin / 4 h / 80 °C

3.1: [D]-sodium hydroxide; water-d2 / 3 h / 23 °C

3.2: Dowex_.(R). 50WX₈ (H⁺) resin

4.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 °C

4.2: 1.25 h / 0 - 23 °C

With [D]-sodium hydroxide; palladium 10% on activated carbon; hydrogen; water-d2; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2011.02.012

Reference yield:

: 19342-33-7
N-acetyl neuraminic acid

: 1312777-17-5
2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-3,3-[(2)H2]-β-neuraminic acid 1,7-lactone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 4.5 h / 100 °C

1.2: Dowex OH^- resin

2.1: triethylamine / methanol / 2 h / 0 - 22 °C

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 22 °C

4.1: sodium hydroxide / water / 0.5 h / 40 °C

4.2: Dowex_.(R). 50WX₈ (H⁺) resin / 4 h / 80 °C

5.1: [D]-sodium hydroxide; water-d2 / 3 h / 23 °C

5.2: Dowex_.(R). 50WX₈ (H⁺) resin

6.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 °C

6.2: 1.25 h / 0 - 23 °C

With hydrogenchloride; [D]-sodium hydroxide; palladium 10% on activated carbon; hydrogen; water-d2; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2011.02.012