N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Base Information

Chemical Name:N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester
CAS No.:1312776-91-2
Molecular Formula:C₂₀H₂₉NO₁₀
Molecular Weight:445.435
Hs Code.:

Synonyms:N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Suppliers and Price of N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

There total 2 articles about N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 56070-37-2
methyl (methyl 5-amino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid)onate

: 1312777-22-2
2,2-dideutero-2-benzyloxyacetyl chloride

: 1312776-91-2
N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Guidance literature:: With triethylamine; In methanol; at 0 - 22 ℃; for 2h;
DOI:10.1016/j.tetasy.2011.02.012

Reference yield:

: 19342-33-7
N-acetyl neuraminic acid

: 1312776-91-2
N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 4.5 h / 100 °C

1.2: Dowex OH^- resin

2.1: triethylamine / methanol / 2 h / 0 - 22 °C

With hydrogenchloride; triethylamine; In methanol;
DOI:10.1016/j.tetasy.2011.02.012

Reference yield:

: 1312776-91-2
N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester

: 1312777-14-2
2-benzyloxycarbonyl-N-([(2)H2]-glycolyl)-β-neuraminic acid 1,7-lactone

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 22 °C

2.1: sodium hydroxide / water / 0.5 h / 40 °C

2.2: Dowex_.(R). 50WX₈ (H⁺) resin / 4 h / 80 °C

3.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 1.25 h / 0 - 23 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2011.02.012