Ethyl glycinate

Base Information

• Chemical Name: Ethyl glycinate
• CAS No.: 459-73-4
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2922499990
• European Community (EC) Number: 207-298-3
• DSSTox Substance ID: DTXSID90196648
• Nikkaji Number: J5.765G
• Wikidata: Q27460686
• ChEMBL ID: CHEMBL2448938
• Mol file: 459-73-4.mol

Synonyms:ethyl glycinate;glycine ethyl ester;glycine ethyl ester, (aminomethyl)phosphonate (1:1);glycine ethyl ester, 1-(14)C-labeled;glycine ethyl ester, hydrochloride

Chemical Property of Ethyl glycinate

Chemical Property:

• Vapor Pressure: 24.7mmHg at 25°C
• Melting Point: 95.5 °C
• Refractive Index: 1.422
• Boiling Point: 109.5 °C at 760 mmHg
• PKA: 7.56±0.29(Predicted)
• PSA: 52.32000
• Density: 1.013 g/cm³
• LogP: 0.20850
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 103.063328530
• Heavy Atom Count: 7
• Complexity: 62.7

Purity/Quality:

99%, ^*data from raw suppliers

H-Gly-Oet 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN
• Uses: Glycine Ethyl Ester

Technology Process of Ethyl glycinate

There total 62 articles about Ethyl glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + glycine (56-40-6,18875-39-3,25718-94-9) → GlyOEt*HCl (459-73-4)

Guidance literature:

With thionyl chloride;

DOI:10.1016/j.mencom.2013.03.013

Reference yield: 96.0%

glycine ethyl ester hydrochloride (623-33-6) → GlyOEt*HCl (459-73-4)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 7h; Reflux;

DOI:10.1016/j.ejmech.2020.112111

Reference yield: 95.0%

C13H14N4O7 → 5,7-dinitroindoline (67932-53-0) + GlyOEt*HCl (459-73-4)

Guidance literature:

With water; In 1,4-dioxane; dichloromethane; at 20 ℃; for 5h; UV-irradiation;

DOI:10.1055/s-2007-985580

upstream raw materials:

nitroacetic acid ethyl ester

ethyl-2-azidoacetate

ethanol

malonic acid-monoazide

Downstream raw materials:

N,N-bis-(2-hydroxyethyl)glycine

N-furfuryl-glycine

N³-((ethoxycarbonyl)-methyl)nicotinamide

ethyl [(2S)-2-(benzyloxycarbonylamino)-3-phenylpropanoylamino]acetate

Refernces

• 1、 Ciuffarin et al.. "-". . p. 2187. Retrieved 1971.
• 2、 Baker,Schlesinger. "-". . p. 1652. Retrieved 1948.
• 3、 Merzhyievskyi, Danylo O.,Shablykin, Oleh V.,Shablykina, Olga V.,Kozytskiy, Andriy V.,Rusanov, Eduard B.,Moskvina, Viktoriia S.,Brovarets, Volodymyr S.. "Functionalized 5-Amino-4-cyanoxazoles, their Hetero- and Macrocyclic Derivatives: Preparation and Synthetic Applications". . p. 6511 - 6523. Retrieved 2021.
• 4、 Bode, Moira L.,Coyanis, E. Mabel,Mosebi, Salerwe,Njengele, Zikhona,Rashamuse, Thompho J.,Sayed, Yasien. "Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction". . . Retrieved 2020/02/13.