7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1337530-96-7
Molecular Formula:C₂₃H₂₁N₅O
Molecular Weight:383.453
Hs Code.:

Synonyms:7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 5 articles about 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-bromo-1-(phenylacetyl)-2,3-dihydro-1H-indole

: 1337532-51-0
5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1337530-96-7
7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: 5-bromo-1-(phenylacetyl)-2,3-dihydro-1H-indole; With potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 20 - 100 ℃; for 3h; Inert atmosphere; Sealed vessel;

5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 - 100 ℃; for 72h; Inert atmosphere; Sealed vessel;

Reference yield:

: 7781-10-4
4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin

: 1337530-96-7
7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: ammonium hydroxide / 48 h / 100 °C / Sealed vessel

3.1: bis(pinacol)diborane; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 20 - 100 °C / Inert atmosphere; Sealed vessel

3.2: 72 h / 20 - 100 °C / Inert atmosphere; Sealed vessel

With ammonium hydroxide; N-Bromosuccinimide; potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1337530-96-7
7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C

2.1: N-Bromosuccinimide / dichloromethane / 20 °C

3.1: ammonium hydroxide / 48 h / 100 °C / Sealed vessel

4.1: bis(pinacol)diborane; potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 20 - 100 °C / Inert atmosphere; Sealed vessel

4.2: 72 h / 20 - 100 °C / Inert atmosphere; Sealed vessel

With ammonium hydroxide; N-Bromosuccinimide; potassium acetate; sodium hydride; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;