5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine

Base Information

• Chemical Name: 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
• CAS No.: 1337532-51-0
• Molecular Formula: C7H7BrN4
• Molecular Weight: 227.063
• Hs Code.: 2933990090
• Mol file: 1337532-51-0.mol

Synonyms:5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine;4-Amino-5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine;5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property of 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine

Chemical Property:

• Melting Point: 196-198°C
• Boiling Point: 414.8±40.0 °C(Predicted)
• PKA: 4.92±0.30(Predicted)
• PSA: 56.73000
• Density: 1.94±0.1 g/cm3(Predicted)
• LogP: 1.89420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Soluble in dichloromethane.

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used in the preparation of indoline derivatives as PERK inhibitors. 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine can be used in the preparation of indoline derivatives as PERK inhibitors.

Technology Process of 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine

There total 5 articles about 5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (1266343-30-9) → 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1337532-51-0)

Guidance literature:

With ammonium hydroxide; at 120 ℃; for 18h;

Reference yield: 70.0%

4-amino-5-bromopyrrolo<2,3-d>pyrimidine (22276-99-9) + methyl iodide (74-88-4) → 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1337532-51-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield:

4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin (7781-10-4) → 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1337532-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 20 °C

2: ammonium hydroxide / 48 h / 100 °C / Sealed vessel

With ammonium hydroxide; N-Bromosuccinimide; In dichloromethane;

upstream raw materials:

4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

4-amino-5-bromopyrrolo<2,3-d>pyrimidine

Downstream raw materials:

7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

5-{1-[(2-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

5-{1-[(3-fluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Refernces

• 1、 -. "PERK INHIBITING INDOLINYL COMPOUNDS". Paragraph 0150; 0151. . Retrieved 2021/03/05.
• 2、 -. "FGFR INHIBITORS AND METHODS OF USE THEREOF". Paragraph 0291. . Retrieved 2020/11/30.