(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

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Chemical Name:(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate
CAS No.:225530-20-1
Molecular Formula:C₃₉H₄₅N₅O₄
Molecular Weight:647.817
Hs Code.:

Synonyms:(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

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Chemical Property of (2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

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Technology Process of (2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

There total 9 articles about (2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 225530-19-8
(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N'-(2-(3-N-triphenylmethyl)amino-pyridinyl)ureidopentanoate

: 225530-20-1
(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

Guidance literature:: With triethylamine; mercury dichloride; In methanol; at 0 ℃; for 0.166667h; Yield given;
DOI:10.1016/S0040-4039(99)00204-X

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 225530-20-1
(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 2-methyl-propan-2-ol / 20 h / 50 °C

2: H₂ / 5 percent Pd/C / ethyl acetate / 5 h / 220 °C

3: 9.66 g / aq. H₂O₂ / tetrahydrofuran / 0 °C

4: 3.06 g / Et₃N / tetrahydrofuran / 87 h / Heating

5: 1.766 g / HgCl₂; Et₃N / methanol / 0.17 h / 0 °C

With hydrogen; dihydrogen peroxide; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)00399-4

Reference yield:

: 53054-02-7
N_α-(1,1-dimethylethoxycarbonyl)-N_δ-(phenylmethoxycarbonyl)-L-ornithine 1,1-dimethylethyl ester

: 225530-20-1
(2S)-tert-butyl 2-N-(tert-butoxycarbonyl)amino-5-N-(2-(1-triphenylmethyl)-1H-imidazo-[4,5-b]-pyridinyl)aminopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5 percent Pd/C / ethyl acetate / 5 h / 220 °C

2: 9.66 g / aq. H₂O₂ / tetrahydrofuran / 0 °C

3: 3.06 g / Et₃N / tetrahydrofuran / 87 h / Heating

4: 1.766 g / HgCl₂; Et₃N / methanol / 0.17 h / 0 °C

With hydrogen; dihydrogen peroxide; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1016/S0040-4020(01)00399-4