cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

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Chemical Name:cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine
CAS No.:1246348-09-3
Molecular Formula:C₂₆H₃₅N₅
Molecular Weight:417.597
Hs Code.:

Synonyms:cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

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Chemical Property of cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

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Technology Process of cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

There total 9 articles about cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1246348-25-3
3-(4-cyclohexylamino-1H-pyrazolo[4,3-c]pyridin-3-yl)-propan-1-ol

: 59349-71-2
(S)-3-phenylpiperidine hydrochloride

: 1246348-09-3
cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

Guidance literature:: 3-(4-cyclohexylamino-1H-pyrazolo[4,3-c]pyridin-3-yl)-propan-1-ol; With triphenylphosphine; In carbon tetrabromide; acetonitrile; at 20 ℃; for 2h; Microwave irradiation;

(S)-3-phenylpiperidine hydrochloride; In carbon tetrabromide; acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1246348-09-3
cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.5 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

5.1: butan-1-ol / 20 - 190 °C / Microwave irradiation

6.1: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 70 °C

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

8.2: 0.58 h / 50 °C

9.1: trifluoroacetic acid / 20 - 70 °C

10.1: triphenylphosphine / carbon tetrabromide; acetonitrile / 2 h / 20 °C / Microwave irradiation

10.2: 0.5 h / 100 °C / Microwave irradiation

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; carbon tetrabromide; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 871836-51-0
4-chloro-1H-pyrazolo [4,3-c]pyridine

: 1246348-09-3
cyclohexyl-{3-[3-((S)-3-phenyl-piperidin-1-yl)-propyl]-1H-pyrazolo[4,3-c]pyridin-4-yl}-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

3.1: butan-1-ol / 20 - 190 °C / Microwave irradiation

4.1: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 70 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

6.2: 0.58 h / 50 °C

7.1: trifluoroacetic acid / 20 - 70 °C

8.1: triphenylphosphine / carbon tetrabromide; acetonitrile / 2 h / 20 °C / Microwave irradiation

8.2: 0.5 h / 100 °C / Microwave irradiation

With lithium aluminium tetrahydride; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; carbon tetrabromide; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;