3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

Base Information

Chemical Name:3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine
CAS No.:197388-41-3
Molecular Formula:C₂₁H₂₈N₂O₃
Molecular Weight:356.465
Hs Code.:

Synonyms:3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

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Chemical Property of 3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

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Technology Process of 3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

There total 7 articles about 3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 197388-32-2
(7-Methoxy-chroman-2-ylmethyl)-[3-(2-methyl-3-nitro-phenoxy)-propyl]-amine

: 197388-41-3
3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

Guidance literature:: With hydrazine; nickel; In ethanol; for 1h; Heating;
DOI:10.1021/jm9703653

Reference yield:

: 5460-31-1
3-nitro-o-cresol

: 197388-41-3
3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / PPh₃, DEAD / tetrahydrofuran / 3 h

2: 75 percent / hydrazine / Raney Ni / ethanol / 1 h / Heating

With triphenylphosphine; hydrazine; diethylazodicarboxylate; nickel; In tetrahydrofuran; ethanol;
DOI:10.1021/jm9703653

Reference yield:

: 38322-74-6
7-methoxy-4-oxo-4H-chromene-2-carboxylic acid ethyl ester

: 197388-41-3
3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / H₂, AcOH / 10percent Pd/C / 120 h / 2585.7 Torr

2: 97 percent / LiBH₄ / tetrahydrofuran / 2 h

3: 75 percent / CBr₄, PPh₃ / CH₂Cl₂ / 12 h / Ambient temperature

4: 92 percent / 2 h / 100 °C

5: 40 percent / PPh₃, DEAD / tetrahydrofuran / 3 h

6: 75 percent / hydrazine / Raney Ni / ethanol / 1 h / Heating

With lithium borohydride; carbon tetrabromide; hydrogen; acetic acid; triphenylphosphine; hydrazine; diethylazodicarboxylate; palladium on activated charcoal; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm9703653