bromomethylenebis(phosphonic acid)

Base Information

• Chemical Name: bromomethylenebis(phosphonic acid)
• CAS No.: 10596-21-1
• Molecular Formula: CH5 Br O6 P2
• Molecular Weight: 254.899
• Hs Code.: 2916190090
• Mol file: 10596-21-1.mol

Synonyms:Phosphonicacid, (bromomethylene)bis- (9CI); Phosphonic acid, (bromomethylene)di-(7CI,8CI)

Chemical Property of bromomethylenebis(phosphonic acid)

Chemical Property:

• Vapor Pressure: 6.83E-13mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 535.5°Cat760mmHg
• PKA: 1.04±0.10(Predicted)
• Flash Point: 277.7°C
• PSA: 134.68000
• Density: 2.63g/cm³
• LogP: 0.02030
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

98%,99%, ^*data from raw suppliers

BromomethylenediphosphonicAcid,90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An organophosphorus analog of biologically active compounds

Technology Process of bromomethylenebis(phosphonic acid)

There total 1 articles about bromomethylenebis(phosphonic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetraisopropyl esters of monobromomethylene bisphosphonic acid (10596-20-0) → [bromo(phosphono)methyl]phosphonic acid (10596-21-1)

Guidance literature:

With hydrogen bromide; In water; Reflux;

DOI:10.1021/bi500101z

Reference yield: 36.0%

[bromo(phosphono)methyl]phosphonic acid (10596-21-1) + triethylamine carbonate (15715-58-9) + 2-nitrophenylmethyl bromide (3958-60-9) → (bromo(hydroxy-((2-nitrobenzyl)oxy)phosphoryl)methyl)phosphonic acid bis(triethylammonium) salt

Guidance literature:

[bromo(phosphono)methyl]phosphonic acid; 2-nitrophenylmethyl bromide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

triethylamine carbonate; In acetonitrile; pH=7.5;

DOI:10.1021/acs.joc.0c01204

Reference yield:

[bromo(phosphono)methyl]phosphonic acid (10596-21-1) + cytidine 5'-monophosphate morpholidate (76742-17-1) → C10H17BrN3O12P3

Guidance literature:

In dimethyl sulfoxide; for 48h;

DOI:10.1021/acs.biochem.6b01230

upstream raw materials:

tetraisopropyl esters of monobromomethylene bisphosphonic acid

Refernces