2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Name:2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428789-88-1
Molecular Formula:C₂₃H₂₉F₃N₄O₄S
Molecular Weight:514.569
Hs Code.:

Synonyms:2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 9 articles about 2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1428790-28-6
2-(4-(aminomethyl)-3-methoxyphenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 124-63-0
methanesulfonyl chloride

: 1428789-88-1
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 23 ℃; for 0.333333h;

Reference yield:

: 91-23-6
2-Nitroanisole

: 1428789-88-1
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 15 h

3.1: sodium nitrite; potassium iodide

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 36 h / 120 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

6.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C

7.2: 1 h

8.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

9.1: pyridine / 0.33 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402585-27-6
ethyl 2-(4-amino-3-methoxyphenyl)propanoate

: 1428789-88-1
2-(3-methoxy-4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium nitrite; potassium iodide

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 36 h / 120 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

4.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

5.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C

5.2: 1 h

6.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

7.1: pyridine / 0.33 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;