isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

Base Information

Chemical Name:isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate
CAS No.:913299-04-4
Molecular Formula:C₂₅H₃₁Cl₂N₃O₃
Molecular Weight:492.445
Hs Code.:

Synonyms:isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

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Chemical Property of isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

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Technology Process of isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

There total 7 articles about isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: isopropyl [2,4-dichloro-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

: 644961-69-3
4-chloro-2-methoxy-6-methylphenylamine

: 913299-04-4
isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

Guidance literature:: isopropyl [2,4-dichloro-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate; 4-chloro-2-methoxy-6-methylphenylamine; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 108h;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 913299-06-6
4-[(E/Z)-1-ethylprop-1-en-1-yl]-1,3-dihydro-2H-benzimidazol-2-one

: 913299-04-4
isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 15 h / 20 °C

2: dmap / 1,2-dichloro-ethane / 0.5 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5: N-chloro-succinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 72 h / 70 °C

6: trichlorophosphate / 48 h / 100 °C

7: 1-methyl-pyrrolidin-2-one / 108 h / 110 °C

With hydrogenchloride; dmap; N-chloro-succinimide; 2,2'-azobis(isobutyronitrile); ammonium formate; potassium carbonate; trichlorophosphate; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 913299-07-7
4-(1-ethylpropyl)-1,3-dihydro-2H-benzimidazol-2-one

: 913299-04-4
isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / 1,2-dichloro-ethane / 0.5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3: hydrogenchloride / ethyl acetate / 1 h / 20 °C

4: N-chloro-succinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 72 h / 70 °C

5: trichlorophosphate / 48 h / 100 °C

6: 1-methyl-pyrrolidin-2-one / 108 h / 110 °C

With hydrogenchloride; dmap; N-chloro-succinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;