2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

Base Information

Chemical Name:2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol
CAS No.:913299-13-5
Molecular Formula:C₂₂H₂₇Cl₂N₃O₂
Molecular Weight:436.381
Hs Code.:

Synonyms:2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

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Chemical Property of 2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

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Technology Process of 2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

There total 8 articles about 2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 913299-04-4
isopropyl [4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

: 913299-13-5
2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; for 2h; Reflux;

Reference yield:

: 913299-06-6
4-[(E/Z)-1-ethylprop-1-en-1-yl]-1,3-dihydro-2H-benzimidazol-2-one

: 913299-13-5
2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 15 h / 20 °C

2: dmap / 1,2-dichloro-ethane / 0.5 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5: N-chloro-succinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 72 h / 70 °C

6: trichlorophosphate / 48 h / 100 °C

7: 1-methyl-pyrrolidin-2-one / 108 h / 110 °C

8: lithium borohydride / tetrahydrofuran / 2 h / Heating / reflux

With hydrogenchloride; dmap; N-chloro-succinimide; lithium borohydride; 2,2'-azobis(isobutyronitrile); ammonium formate; potassium carbonate; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: isopropyl [2,4-dichloro-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]acetate

: 913299-13-5
2-[4-chloro-2-[(4-chloro-2-methoxy-6-methylphenyl)amino]-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 108 h / 110 °C

2: lithium borohydride / tetrahydrofuran / 2 h / Heating / reflux

With lithium borohydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;