(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

Base Information

Chemical Name:(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal
CAS No.:1369535-03-4
Molecular Formula:C₁₇H₁₄F₄N₂O
Molecular Weight:338.305
Hs Code.:

Synonyms:(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

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Chemical Property of (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

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Technology Process of (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

There total 4 articles about (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1369535-02-3
(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)-2-propen-1-ol

: 1369535-03-4
(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm300101n

Reference yield:

: 910487-53-5
2-(dimethylamino)-6-trifluoromethylnicotinic acid

: 1369535-03-4
(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 29 h / 20 °C / Inert atmosphere

3: sodium hydride / toluene / 120 h / 100 °C / Inert atmosphere

4: diisobutylaluminium hydride / tetrahydrofuran / 7.5 h / -78 - 0 °C / Inert atmosphere

5: manganese(IV) oxide / dichloromethane / 6 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300101n

Reference yield:

: 1369535-01-2
ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

: 1369535-03-4
(E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)propenal

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 7.5 h / -78 - 0 °C / Inert atmosphere

2: manganese(IV) oxide / dichloromethane / 6 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300101n