ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

Base Information

Chemical Name:ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate
CAS No.:1369535-01-2
Molecular Formula:C₁₉H₁₈F₄N₂O₂
Molecular Weight:382.358
Hs Code.:

Synonyms:ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

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Chemical Property of ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

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Technology Process of ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

There total 4 articles about ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1369535-00-1
2-(dimethylamino)-3-(4-fluorobenzoyl)-6-trifluoromethylpyridine

: 1369535-01-2
ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

Guidance literature:: With sodium hydride; In toluene; at 100 ℃; for 120h; Inert atmosphere;
DOI:10.1021/jm300101n

Reference yield:

: 910487-53-5
2-(dimethylamino)-6-trifluoromethylnicotinic acid

: 1369535-01-2
ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 29 h / 20 °C / Inert atmosphere

3: sodium hydride / toluene / 120 h / 100 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300101n

Reference yield:

: 1369534-99-5
2-(dimethylamino)-N-methoxy-N-methyl-6-trifluoromethylnicotinamide

: 1369535-01-2
ethyl (E)-3-(2-dimethylamino-6-trifluoromethylpyridin-3-yl)-3-(4-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 29 h / 20 °C / Inert atmosphere

2: sodium hydride / toluene / 120 h / 100 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; toluene; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm300101n