2,5-dibromo-3-methyl benzoic acid methyl ester

Base Information

• Chemical Name: 2,5-dibromo-3-methyl benzoic acid methyl ester
• CAS No.: 908597-10-4
• Molecular Formula: C₉H₈Br₂O₂
• Molecular Weight: 307.969
• Mol file: 908597-10-4.mol

Synonyms:2,5-dibromo-3-methyl benzoic acid methyl ester

Chemical Property of 2,5-dibromo-3-methyl benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dibromo-3-methyl benzoic acid methyl ester

There total 8 articles about 2,5-dibromo-3-methyl benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-2-nitrobenzoic acid (5437-38-7) → 2,5-dibromo-3-methyl benzoic acid methyl ester (908597-10-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethanol / 20 °C / 25857.4 Torr

2: 88 percent / HBr; DMSO / 16 h

3: 55 percent / NaNO₂; CuBr; HBr / dimethylsulfoxide / 3 h / 40 °C

4: 0.367 g / sulfuric acid / 16 h / Heating

With sulfuric acid; hydrogen bromide; hydrogen; dimethyl sulfoxide; copper(I) bromide; sodium nitrite; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; 3: Sandmeyer reaction;

DOI:10.1021/jo060553d

Reference yield:

(E)-2-(hydroxyimino)-N-(o-tolyl)acetamide → 2,5-dibromo-3-methyl benzoic acid methyl ester (908597-10-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 32 percent / sulfuric acid / 60 - 80 °C

2.1: 88 percent / Br₂ / CHCl₃ / 24 h / Heating

3.1: NaOH; NaCl / H₂O / 0.5 h

3.2: 99 percent / H₂O₂; NaOH / H₂O / 1.5 h

4.1: 55 percent / NaNO₂; CuBr; HBr / dimethylsulfoxide / 3 h / 40 °C

5.1: 0.367 g / sulfuric acid / 16 h / Heating

With sodium hydroxide; sulfuric acid; hydrogen bromide; bromine; sodium chloride; copper(I) bromide; sodium nitrite; In chloroform; water; dimethyl sulfoxide; 4.1: Sandmeyer reaction;

DOI:10.1021/jo060553d

Reference yield:

7-methyl-1H-indole-2,3-dione (1127-59-9) → 2,5-dibromo-3-methyl benzoic acid methyl ester (908597-10-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 88 percent / Br₂ / CHCl₃ / 24 h / Heating

2.1: NaOH; NaCl / H₂O / 0.5 h

2.2: 99 percent / H₂O₂; NaOH / H₂O / 1.5 h

3.1: 55 percent / NaNO₂; CuBr; HBr / dimethylsulfoxide / 3 h / 40 °C

4.1: 0.367 g / sulfuric acid / 16 h / Heating

With sodium hydroxide; sulfuric acid; hydrogen bromide; bromine; sodium chloride; copper(I) bromide; sodium nitrite; In chloroform; water; dimethyl sulfoxide; 3.1: Sandmeyer reaction;

DOI:10.1021/jo060553d

upstream raw materials:

2,5-dibromo-3-methylbenzoic acid

methanol

7-methyl-1H-indole-2,3-dione

5-bromo-7-methyl-2,3-d1H ydro-1H-indole-2,3-dione

Refernces