N⁶-benzoyl-5'-deoxy-5'-iodoadenosine

Base Information

• Chemical Name: N⁶-benzoyl-5'-deoxy-5'-iodoadenosine
• CAS No.: 6044-47-9
• Molecular Formula: C₁₇H₁₆IN₅O₄
• Molecular Weight: 481.25
• Mol file: 6044-47-9.mol

Synonyms:N⁶-benzoyl-5'-deoxy-5'-iodoadenosine

Chemical Property of N⁶-benzoyl-5'-deoxy-5'-iodoadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-5'-deoxy-5'-iodoadenosine

There total 1 articles about N⁶-benzoyl-5'-deoxy-5'-iodoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N6-benzoyl-5'-deoxy-5'-iodoadenosine (6044-47-9)

Guidance literature:

N6-Benzoyl-5'-deoxy-5'-jod-2',3' -O-isopropylidenadenosin(26b),90percentAmeisensaeure,NH4OH.;

DOI:10.1021/jo01317a019

Reference yield: 69.0%

phosgene (75-44-5) + N6-benzoyl-5'-deoxy-5'-iodoadenosine (6044-47-9) → N6-benzoyl-2',3'-O-carbonyl-5'-deoxy-5'-iodoadenosine (81307-81-5)

Guidance literature:

With pyridine; In benzene; at -35 ℃; for 0.5h;

DOI:10.1016/S0008-6215(00)81045-9

Reference yield:

N6-benzoyl-5'-deoxy-5'-iodoadenosine (6044-47-9) → (2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-2-[(2,4-dinitro-phenylamino)-methyl]-2-methoxy-tetrahydro-furan-3,4-diol; hydrate

Guidance literature:

Multi-step reaction with 8 steps

1: 69 percent / pyridine / benzene / 0.5 h / -35 °C

2: 77 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / pyridine / 3 h / 20 °C

3: pyridine / 48 h / Ambient temperature

4: 94 percent / iodine, lead carbonate / 1 h / Ambient temperature

5: 1.) 0.2 M barium hydroxide, 2.) pyridine / 1.) methanol, 15 min., 2.) methanol, 48 h., room temp.

6: 1.) sodium azide, 2.) saturated methanolic ammonia / 1.) dimethyl sulfoxide, 110 deg C, 24 h., 2.) 100 deg C, 1.5 h.

7: 100 mg / hydrogen / 10percent Pd/C / ethanol / 1 h / 760 Torr

8: sodium hydrogencarbonate / ethanol / 0.08 h

With pyridine; barium dihydroxide; sodium azide; lead Carbonate; DBN; ammonia; hydrogen; iodine; sodium hydrogencarbonate; palladium on activated charcoal; In pyridine; ethanol; benzene;

DOI:10.1016/S0008-6215(00)81045-9

Downstream raw materials:

N⁶-benzoyl-2',3'-O-carbonyl-5'-deoxy-5'-iodoadenosine

N⁶-benzoyl-9-(2,3-O-carbonyl-5-deoxy-β-D-erythro-pent-4-enofuranosyl)adenine

N⁶,N⁶-dibenzoyl-9-(2,3-O-carbonyl-5-deoxy-β-D-erythro-pent-4-enofuranosyl)adenine

N⁶,N⁶-dibenzoyl-2',3'-O-carbonyl-5'-deoxy-5'-iodo-4'-methoxyadenosine