(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

Base Information

Chemical Name:(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide
CAS No.:1311255-49-8
Molecular Formula:C₁₂H₁₃F₃N₂O₃
Molecular Weight:290.242
Hs Code.:

Synonyms:(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

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Chemical Property of (R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

Chemical Property:

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Technology Process of (R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

There total 3 articles about (R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1311255-47-6
(R)-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzonitrile

: 1311255-49-8
(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

Guidance literature:: With hydroxylamine; In ethanol; water; at 60 ℃; for 18h;

Reference yield:

: 124811-71-8
4-hydroxy-3-(trifluoromethyl)benzonitrile

: 1311255-49-8
(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 18 h / 60 °C

With di-isopropyl azodicarboxylate; hydroxylamine; triphenylphosphine; In tetrahydrofuran; ethanol; water;

Reference yield:

: 261951-87-5
4-methoxy-3-(trifluoromethyl)benzonitrile

: 1311255-49-8
(R)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine hydrochloride / 0.67 h / 200 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: hydroxylamine / ethanol; water / 18 h / 60 °C

With di-isopropyl azodicarboxylate; hydroxylamine; pyridine hydrochloride; triphenylphosphine; In tetrahydrofuran; ethanol; water;