1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

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Chemical Name:1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone
CAS No.:161109-97-3
Molecular Formula:C₄₀H₄₉N₅O₆Si
Molecular Weight:723.944
Hs Code.:

Synonyms:1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

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Chemical Property of 1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

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Technology Process of 1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

There total 4 articles about 1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 161109-97-3
1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / imidazole / pyridine / 20 h / Ambient temperature

2: 76 percent / DMAP / acetonitrile / 20 h / Ambient temperature

3: 88 percent / AIBN, Bu₃SnH / toluene / 3 h / 85 °C

4: 71 percent / o-chlorophenylphosphorodichloridate / pyridine / 72 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 2-chlorophenyl dichlorophosphate; In pyridine; toluene; acetonitrile;
DOI:10.1080/15257779408012162

Reference yield:

: 81246-79-9
5'-dimethoxytrityluridine

: 161109-97-3
1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / imidazole / pyridine / 20 h / Ambient temperature

2: 76 percent / DMAP / acetonitrile / 20 h / Ambient temperature

3: 88 percent / AIBN, Bu₃SnH / toluene / 3 h / 85 °C

4: 71 percent / o-chlorophenylphosphorodichloridate / pyridine / 72 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 2-chlorophenyl dichlorophosphate; In pyridine; toluene; acetonitrile;
DOI:10.1080/15257779408012162

Reference yield:

: 161109-84-8
5'-O-dimethoxytrityl-2'-O-thexyldimethylsilyluridine

: 161109-97-3
1-(5-O-dimethoxytrityl-2-O-thexyldimethylsilyl-3-deoxy-β-D-erythro-pentofuranosyl)-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidone

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / DMAP / acetonitrile / 20 h / Ambient temperature

2: 88 percent / AIBN, Bu₃SnH / toluene / 3 h / 85 °C

3: 71 percent / o-chlorophenylphosphorodichloridate / pyridine / 72 h / Ambient temperature

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 2-chlorophenyl dichlorophosphate; In pyridine; toluene; acetonitrile;
DOI:10.1080/15257779408012162