1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

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Chemical Name:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester
CAS No.:573659-00-4
Molecular Formula:C₃₀H₄₂FNO₃Si
Molecular Weight:511.752
Hs Code.:

Synonyms:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

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Chemical Property of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

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Technology Process of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

There total 3 articles about 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

: 573659-00-4
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / Et₃N / dimethylformamide

2: DIBAL / CH₂Cl₂ / -78 °C

3: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol034707c

Reference yield:

: 419571-31-6
dibenzyl cyclobutane-1,1-dicarboxylate

: 573659-00-4
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/ol034707c