dibenzyl cyclobutane-1,1-dicarboxylate

Base Information

Chemical Name:dibenzyl cyclobutane-1,1-dicarboxylate
CAS No.:419571-31-6
Molecular Formula:C₂₀H₂₀O₄
Molecular Weight:324.376
Hs Code.:

Synonyms:dibenzyl cyclobutane-1,1-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl cyclobutane-1,1-dicarboxylate

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Technology Process of dibenzyl cyclobutane-1,1-dicarboxylate

There total 1 articles about dibenzyl cyclobutane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

: 100-39-0
benzyl bromide

: 419571-31-6
dibenzyl cyclobutane-1,1-dicarboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ol034707c

Reference yield:

: 419571-31-6
dibenzyl cyclobutane-1,1-dicarboxylate

: 419571-30-5
benzyl 1-formylcyclobutanecarboxylate

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1021/ol034707c

Reference yield:

: 419571-31-6
dibenzyl cyclobutane-1,1-dicarboxylate

: 1-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: NaB(OAc)3H / CH₂Cl₂

3: TBAF / tetrahydrofuran

4: (COCl)2; DMSO; (i-Pr)2NEt / CH₂Cl₂ / -78 °C

5: NaB(OAc)3H / CH₂Cl₂

6: H₂ / Pd/C / methanol

With oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 4: Swern oxidation;
DOI:10.1021/ol034707c