2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

Base Information

Chemical Name:2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one
CAS No.:221122-19-6
Molecular Formula:C₁₆H₁₈F₂N₂OS
Molecular Weight:324.395
Hs Code.:

2-<i>sec</i>-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3<i>H</i>-pyrimidin-4-one

Synonyms:2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

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Chemical Property of 2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

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Technology Process of 2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

There total 4 articles about 2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 513-48-4,52152-71-3
2-butyl iodide

: 221121-68-2
6-(2,6-difluorophenylmethyl)-3,4-dihydro-5-methyl-2-thioxopyrimidin-4(3H)-one

: 221122-19-6
2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm980260f

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 221122-19-6
2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile

2: 1.) Et₃N, MgCl₂ / 1.) CH₃CN, RT, 2 h, 2.) CH₃CN, a) RT, overnight, b) reflux, 2 h

3: 56 percent / NaOEt / ethanol / 5 h / Heating

4: 49 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With sodium ethanolate; potassium carbonate; triethylamine; magnesium chloride; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980260f

Reference yield:

: 221121-33-1
2-(2,6-difluoro-phenyl)-1-imidazol-1-yl-ethanone

: 221122-19-6
2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, MgCl₂ / 1.) CH₃CN, RT, 2 h, 2.) CH₃CN, a) RT, overnight, b) reflux, 2 h

2: 56 percent / NaOEt / ethanol / 5 h / Heating

3: 49 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With sodium ethanolate; potassium carbonate; triethylamine; magnesium chloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980260f