4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane
CAS No.:816431-00-2
Molecular Formula:C₃₈H₅₀N₆O₄
Molecular Weight:654.853
Hs Code.:

Synonyms:4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

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Chemical Property of 4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

There total 3 articles about 4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 90281-17-7
1,7-dimethylcyclen

: 816430-99-6
3-(benzyloxy)-1-(2-chloroethyl)-1H-pyridin-2-one

: 816431-00-2
4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1039/b411165f

Reference yield:

: 95215-72-8
2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid

: 816431-00-2
4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / BH₃ / tetrahydrofuran / 2 h / 20 °C

2: 86 percent / Et₃N; tosyl chloride / CH₂Cl₂ / 20 °C

3: 40 percent / K₂CO₃ / acetonitrile / 48 h / 20 °C

With borane; potassium carbonate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/b411165f

Reference yield:

: 238420-38-7
3-(benzyloxy)-1-(2-hydroxyethyl)-2(1H)-pyridinone

: 816431-00-2
4(N),10(N)-bis[2-(3-benzyloxy-2-oxo-2H-pyridin-1-yl)ethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N; tosyl chloride / CH₂Cl₂ / 20 °C

2: 40 percent / K₂CO₃ / acetonitrile / 48 h / 20 °C

With potassium carbonate; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; acetonitrile;
DOI:10.1039/b411165f