2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

Base Information

Chemical Name:2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide
CAS No.:1300746-65-9
Molecular Formula:C₂₄H₂₆ClN₃O₂S
Molecular Weight:456.008
Hs Code.:

Synonyms:2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

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Chemical Property of 2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

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Technology Process of 2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

There total 2 articles about 2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1300746-67-1
[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]acetic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 1300746-65-9
2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1260530-39-9
methyl [5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]acetate

: 1300746-65-9
2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,4-dioxane / 20 °C

1.2: pH ~ 6

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 16.0%

: 1445-45-0
Trimethyl orthoacetate

: 1300746-65-9
2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide

: 1300746-07-9
2-[6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-cyclohexylacetamide

Guidance literature:: 2-[5-(4-chlorophenyl)-7-(methyloxy)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-N-cyclohexylacetamide; With hydrazine hydrate; In methanol; at 0 - 40 ℃; for 1.5h;

Trimethyl orthoacetate; With pyridinium p-toluenesulfonate; In methanol; for 0.75h; Reflux;