5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

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Chemical Name:5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one
CAS No.:178488-69-2
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

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Chemical Property of 5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

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Technology Process of 5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

There total 8 articles about 5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2-Methyl-malonic acid ethyl ester (Z)-1-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-but-1-enyl ester

: 178488-69-2
5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1021/jo960221g

Reference yield:

: 83126-01-6
(E)-1-(3-bromo-2-methylprop-1-en-1-yl)benzene

: 178488-69-2
5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) lithium diisopropylamide / 1) THF, -78 deg C, 20 min; 2) THF, -78 deg C, 1 h

2: 73 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.75 h / -78 °C

3: diethyl ether / 1 h / Ambient temperature

4: 95 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 °C

5: 1.) hexamethyldisilazane, n-BuLi / 1) THF, -78 deg C, 45 min; 2) THF, hexane, -78 deg C, 2 h

6: 48 percent / PTSA / toluene / Heating

With n-butyllithium; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo960221g

Reference yield:

: 141567-53-5
4-hydroxymethyl-2-methyloxazole

: 178488-69-2
5-Ethyl-4-hydroxy-3-methyl-6-[2-((E)-3-methyl-4-phenyl-but-3-enyl)-oxazol-4-yl]-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) lithium diisopropylamide / 1) THF, -78 deg C, 20 min; 2) THF, -78 deg C, 1 h

2: 73 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.75 h / -78 °C

3: diethyl ether / 1 h / Ambient temperature

4: 95 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 °C

5: 1.) hexamethyldisilazane, n-BuLi / 1) THF, -78 deg C, 45 min; 2) THF, hexane, -78 deg C, 2 h

6: 48 percent / PTSA / toluene / Heating

With n-butyllithium; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo960221g