141567-53-5Relevant articles and documents
Total synthesis of the virginiamycin antibiotic 14,15-anhydropristinamycin IIB
Entwistle, David A.,Jordan, Stuart I.,Montgomery, John,Pattenden, Gerald
, p. 1315 - 1317 (1996)
A total synthesis of the virginiamycin 14,15-anhydropristinamycin IIB 16 has been achieved from chiral, non-racemic starting materials, and using a route which features an intramolecular Stille coupling reaction, viz. 14→15, as the key stratagem. The virginiamycin 16 was identical with an authentic sample produced from a Streptomyces fermentation process.
AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES
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Page/Page column 107, (2018/11/10)
In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
PYRROLE ANTIFUNGAL AGENTS
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Page/Page column 151, (2009/12/05)
The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
Oxidative rearrangements of isobenzofurans: Studies toward the synthesis of the ajudazols
Hobson, Stephen J.,Parkin, Andrew,Marquez, Rodolfo
supporting information; experimental part, p. 2813 - 2816 (2009/05/27)
(Chemical Equation Presented) We present a new facet of isobenzofuran chemistry which allows for its efficient manipulation to generate biologically relevant entities. This methodology has been successfully applied toward the synthesis of ajudazol A.
