(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

Base Information

Chemical Name:(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester
CAS No.:403647-96-1
Molecular Formula:C₃₃H₄₅NO₅SSi₂
Molecular Weight:623.961
Hs Code.:

(2-{2-[3,4-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid <i>S</i>-methyl ester

Synonyms:(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

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Chemical Property of (2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

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Technology Process of (2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

There total 7 articles about (2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 403647-95-0
1-(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-2,2,2-tris-methylsulfanyl-ethanone

: 403647-96-1
(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

Guidance literature:: With N-Bromosuccinimide; water; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/S0040-4039(01)01767-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 403647-96-1
(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: nBuLi / tetrahydrofuran / 2 h / -95 °C

2.2: 57 percent / tetrahydrofuran / 0.5 h / -95 °C

3.1: 52 percent / NBS; H₂O / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; water; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)01767-1

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 403647-96-1
(2-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinyl}-8-methoxy-quinolin-7-yl)-oxo-thioacetic acid S-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / 12 h / 140 °C

2.1: 74 percent / H₂O; pyridine / 3 h / 100 °C

3.1: 84 percent / imidazole / dimethylformamide / 12 h / 20 °C

4.1: nBuLi / tetrahydrofuran / 2 h / -95 °C

4.2: 57 percent / tetrahydrofuran / 0.5 h / -95 °C

5.1: 52 percent / NBS; H₂O / tetrahydrofuran / 2 h / 20 °C

With pyridine; 1H-imidazole; N-Bromosuccinimide; n-butyllithium; water; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)01767-1