Technology Process of C28H25BrO4
There total 11 articles about C28H25BrO4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C13H20BrO5P;
With
potassium tert-butylate;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
C19H16O3;
In
tetrahydrofuran;
at -78 - 25 ℃;
Inert atmosphere;
DOI:10.1002/anie.201002264
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; acetic acid / 36 h / 25 °C / Inert atmosphere
2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
3.1: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
4.1: sodium acetate / 1 h / 140 °C / Inert atmosphere
5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
5.2: 0 - 25 °C
6.1: potassium tert-butylate / tetrahydrofuran / -78 °C / Inert atmosphere
6.2: 2 h / -78 - 25 °C
With
potassium tert-butylate; water; hydrogen; bromine; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
2.1: Stobbe Condensation / 6.1: Horner-Wadsworth-Emmons Olefination;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
1.2: 0 - 25 °C
2.1: potassium tert-butylate / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 25 °C
With
potassium tert-butylate; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane;
2.1: Horner-Wadsworth-Emmons Olefination;
