N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Base Information

Chemical Name:N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide
CAS No.:135685-10-8
Molecular Formula:C₁₇H₂₇N₅O₈S
Molecular Weight:461.496
Hs Code.:

N-<2-<N-<(tert-butyloxy)carbonyl>-N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Synonyms:N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Suppliers and Price of N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Chemical Property:

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Technology Process of N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

There total 9 articles about N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-Amino-2-nitro-benzyloxy)-isoindole-1,3-dione

: 135685-10-8
N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂, conc. aq. HCl, AcOH, 2.) SO₂, aq. CuCl₂ / 1.) -5 deg C - deg C, 15 min, 2.) from 0 deg C to RT, 3 h

2: 81.9 percent / N,N-diisopropylethylamine / tetrahydrofuran / 3.5 h / 0 - 20 °C

3: 46 percent / hydrazine / ethanol / 3 h / 80 °C

4: 2.) aq. NH₄Cl / 1.) toluene, 80 deg C, 18 h, 2.) toluene, RT, 30 min

With hydrogenchloride; sulfur dioxide; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; copper dichloride; hydrazine; sodium nitrite; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a024

Reference yield:

: 135685-05-1
N,N-bis<(tert-butyloxy)carbonyl>-4-methyl-3-nitroaniline

: 135685-10-8
N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-bromosuccinimide (NBS), dibenzoyl peroxide / CCl₄ / 20 h / Heating; Irradiation

2: Et₃N / acetonitrile / 6 h / Heating

3: CF₃CO₂H / CH₂Cl₂ / 0 - 6 °C

4: 1.) NaNO₂, conc. aq. HCl, AcOH, 2.) SO₂, aq. CuCl₂ / 1.) -5 deg C - deg C, 15 min, 2.) from 0 deg C to RT, 3 h

5: 81.9 percent / N,N-diisopropylethylamine / tetrahydrofuran / 3.5 h / 0 - 20 °C

6: 46 percent / hydrazine / ethanol / 3 h / 80 °C

7: 2.) aq. NH₄Cl / 1.) toluene, 80 deg C, 18 h, 2.) toluene, RT, 30 min

With hydrogenchloride; N-Bromosuccinimide; sulfur dioxide; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; hydrazine; sodium nitrite; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00114a024

Reference yield:

: 135685-06-2
C₁₇H₂₃BrN₂O₆

: 135685-10-8
N-<2--N-methylamino>ethyl>-N-methyl-3-nitro-4-<(ureidooxy)methyl>benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / acetonitrile / 6 h / Heating

2: CF₃CO₂H / CH₂Cl₂ / 0 - 6 °C

3: 1.) NaNO₂, conc. aq. HCl, AcOH, 2.) SO₂, aq. CuCl₂ / 1.) -5 deg C - deg C, 15 min, 2.) from 0 deg C to RT, 3 h

4: 81.9 percent / N,N-diisopropylethylamine / tetrahydrofuran / 3.5 h / 0 - 20 °C

5: 46 percent / hydrazine / ethanol / 3 h / 80 °C

6: 2.) aq. NH₄Cl / 1.) toluene, 80 deg C, 18 h, 2.) toluene, RT, 30 min

With hydrogenchloride; sulfur dioxide; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; hydrazine; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00114a024