benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

Base Information

Chemical Name:benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate
CAS No.:227612-05-7
Molecular Formula:C₂₈H₃₁N₃O₃S
Molecular Weight:489.638
Hs Code.:

benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2-<methyl(phenyl)amino>-2-oxoethyl>amino>-2-thioxoethyl>carbamate

Synonyms:benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

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Technology Process of benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

There total 3 articles about benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 227612-05-7
benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine, 2.) H₂S / 1.) THF, -10 deg C, 5 min, 2.) THF, -10 deg C, 1 h

2: CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) ZnCl₂, 2.) HCl / multistep reaction; 1.) AcOH, rt, 20 min, 2.) AcOH, rt, 30 min

With 4-methyl-morpholine; hydrogenchloride; hydrogen sulfide; zinc(II) chloride; isobutyl chloroformate; In dichloromethane;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5

Reference yield:

: 92507-06-7
(S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanethioic S-acid

: 227612-05-7
benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) ZnCl₂, 2.) HCl / multistep reaction; 1.) AcOH, rt, 20 min, 2.) AcOH, rt, 30 min

With hydrogenchloride; zinc(II) chloride; In dichloromethane;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5

Reference yield:

: 238748-86-2
benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-thioxoethyl>amino>-2-oxoethyl>carbamate

: 227612-05-7
benzyl N-<(1S)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

: benzyl N-<(1R)-1-benzyl-2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

Guidance literature:: With hydrogenchloride; zinc(II) chloride; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) AcOH, rt, 20 min, 2.) AcOH, rt, 30 min;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5