(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

Base Information

Chemical Name:(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone
CAS No.:1189689-05-1
Molecular Formula:C₂₃H₂₈N₂O₃S
Molecular Weight:412.553
Hs Code.:

Synonyms:(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

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Chemical Property of (R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

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Technology Process of (R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

There total 3 articles about (R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110-89-4
piperidine

: 814-68-6,25189-84-8
acryloyl chloride

: 543745-58-0
N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine

: 1189689-05-1
(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

Guidance literature:: piperidine; acryloyl chloride; With potassium carbonate; In toluene; at 20 ℃; for 1h;

N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine; With palladium diacetate; triphenylphosphine; In toluene; at 120 ℃; for 16h; Inert atmosphere; Autoclave;
DOI:10.1002/ejoc.201001621

Reference yield:

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 1189689-05-1
(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / toluene / 1 h / 20 °C

2.2: 16 h / 120 °C / Inert atmosphere; Autoclave

With potassium carbonate; triethylamine; In dichloromethane; toluene; 2.2: Heck-aza-Michael reaction;
DOI:10.1002/ejoc.201001621

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1189689-05-1
(R,S)-1-(piperidin-1-yl)-2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / toluene / 1 h / 20 °C

2.2: 16 h / 120 °C / Inert atmosphere; Autoclave

With potassium carbonate; triethylamine; In dichloromethane; toluene; 2.2: Heck-aza-Michael reaction;
DOI:10.1002/ejoc.201001621