65185-58-2

Basic information

• Product Name: 2-Bromophenethylamine
• Synonyms: RARECHEM AL BW 0201;BENZENEETHANAMINE, 2-BROMO-;2-BROMOPHENETHYLAMINE;2-(2-bromophenyl)ethanamine;2-bromophenylethyl amine;2-Bromophenethylamine,99%;2-BroMo-benzeneethanaMine;2-BroMophenethylaMine 97%
• CAS NO: 65185-58-2
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: Halides;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Amines;C8;Nitrogen Compounds
• Mol File: 65185-58-2.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 253 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 1.396 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0137mmHg at 25°C
• Refractive Index: n20/D 1.5770(lit.)
• Storage Temp.: Store under Nitrogen
• PKA: 9.52±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Bromophenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromophenethylamine(65185-58-2)
• EPA Substance Registry System: 2-Bromophenethylamine(65185-58-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 65185-58-2(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

2-(2-Bromophenyl)ethylamine is used as a pharmaceutical intermediate.

InChI:InChI=1/C8H10BrN/c9-8-4-2-1-3-7(8)5-6-10/h1-4H,5-6,10H2/p+1

Upstream product

• 1074-15-3 1-bromo-2-(2-bromoethyl)benzene 
• 65999-53-3 2-(2-bromophenyl)acetamide 
• 18698-97-0 ortho-bromophenylacetic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 75767-95-2 N-<β-(2-bromophenyl)ethyl>phthalimide 

Downstream Products

• 97456-89-8 [2-(2-Bromo-phenyl)-ethyl]-(6-iodo-benzo[1,3]dioxol-5-ylmethyl)-amine; hydrochloride 
• 140202-11-5 ethyl <2-(2-bromophenyl)ethyl>carbamate 
• 791544-33-7 [2-(2-Bromo-phenyl)-ethyl]-(2-iodo-benzyl)-amine 
• 164020-64-8 N-benzylidene-2-bromobenzeneethanamine 
• 142387-79-9 2-bromo-N-(1-ethylpropylidene)benzeneethanamine 
• 65185-63-9 N_.N'-Bis(o-bromphenaethyl)harnstoff 
• 210095-86-6 N-(2-bromophenethyl) benzamide 
• 221022-34-0 N-[2-(2-bromophenyl)ethyl]-3,4-dimethoxybenzamide 
• 496-15-1 1-indoline 
• 337965-99-8 [2-(2-bromo-phenyl)-ethyl]-isopropylidene-amine 
• 809233-18-9 [2-(2-bromophenyl)ethyl]-[2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]amine 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 
• 406954-91-4 N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide 

Relevant articles and documents

Reaction of Diisobutylaluminum Borohydride, a Binary Hydride, with Selected Organic Compounds Containing Representative Functional Groups

The binary hydride, diisobutylaluminum borohydride [(iBu)2AlBH4], synthesized from diisobutylaluminum hydride (DIBAL) and borane dimethyl sulfide (BMS) has shown great potential in reducing a variety of organic functional groups. This unique binary hydride, (iBu)2AlBH4, is readily synthesized, versatile, and simple to use. Aldehydes, ketones, esters, and epoxides are reduced very fast to the corresponding alcohols in essentially quantitative yields. This binary hydride can reduce tertiary amides rapidly to the corresponding amines at 25 °C in an efficient manner. Furthermore, nitriles are converted into the corresponding amines in essentially quantitative yields. These reactions occur under ambient conditions and are completed in an hour or less. The reduction products are isolated through a simple acid-base extraction and without the use of column chromatography. Further investigation showed that (iBu)2AlBH4 has the potential to be a selective hydride donor as shown through a series of competitive reactions. Similarities and differences between (iBu)2AlBH4, DIBAL, and BMS are discussed.

COMPOUNDS

Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.

Fe3O4-SiO2-P4VP pH-sensitive microgel for immobilization of nickel nanoparticles: An efficient heterogeneous catalyst for nitrile reduction in water

Fe3O4 magnetic nanoparticles (MNPs) were modified with (3-aminopropyl)triethoxysilane through silanization. An atom transfer radical polymerization-initiating site immobilized onto amine-functionalized Fe3O4 MNPs. The surface-initiated atom transfer radical polymerization of 4-vinylpyridine was then performed in the presence of Fe 3O4-SiO2-Br nanoparticles, which led to the formation of Fe3O4-SiO2-P4VP [P4VP=poly(4-vinylpyridine)] hybrid microgels cross-linked with Fe 3O4 MNPs. Our approach uses polymer microgels as templates for the synthesis of nickel nanoparticles (NiNPs). The tunable properties of synthesized NiNPs@Fe3O4-SiO2-P4VP pH-sensitive microgels were used in the catalytic reduction of aliphatic and aromatic nitriles. Moreover, the catalytic activity of metal nanocomposites that can be modulated by the volume transition of microgel structures with changing pH has been evaluated. TEM, X-ray photoelectron spectroscopy, thermogravimetric analysis, atomic absorption spectroscopy, XRD, UV/Vis spectroscopy, and FTIR spectroscopy were used to characterize the resultant catalyst. Mystery solved: Our approach uses polymer microgels as templates for the synthesis of nickel nanoparticles. The tunable properties of synthesized NiNPs@Fe3O 4-SiO2-P4VP [NiNPs=nickel nanoparticles; P4VP=poly(4-vinylpyridine)] pH-sensitive microgels are used in the catalytic reduction of aliphatic and aromatic nitriles. Moreover, the catalytic activity of metal nanocomposites that can be modulated by the volume transition of microgel structures with changing pH has been evaluated. Copyright