3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

Base Information

Chemical Name:3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine
CAS No.:288309-80-8
Molecular Formula:C₂₄H₂₄N₄O₄S
Molecular Weight:464.545
Hs Code.:

Synonyms:3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

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Technology Process of 3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

There total 7 articles about 3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288309-40-0
Methyl (E)-3-(3-cyanophenyl)-4-methoxy-2-butenoate

: 75-24-1
trimethylaluminum

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 288309-41-1
(2E)-N-[4-(2-{[(tert-butyl)amino]sulfonyl}phenyl)phenyl]-3-(3-cyanophenyl)-4-methoxybut-2-enamide

: 288309-80-8
3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

Guidance literature:: With ammonium acetate; hydrogenchloride; trifluoroacetic acid; In methanol; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 66762-68-3
ethyl 4-methoxy-3-oxobutanoate

: 288309-80-8
3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / -78 °C

2: Pd(Ph₃P)4; K₃PO₄ / dioxane / Heating

3: AlMe₃ / CH₂Cl₂

4: HCl(g); MeOH

5: NH₄OAc

With hydrogenchloride; methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; trimethylaluminum; triethylamine; In 1,4-dioxane; dichloromethane; 3: Weinreb amidation / 4: Pinner reaction;
DOI:10.1016/S0960-894X(02)00199-3

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 288309-80-8
3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1: AlMe₃ / CH₂Cl₂

2: HCl(g); MeOH

3: NH₄OAc

With hydrogenchloride; methanol; ammonium acetate; trimethylaluminum; In dichloromethane; 1: Weinreb amidation / 2: Pinner reaction;
DOI:10.1016/S0960-894X(02)00199-3