(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

Base Information

Chemical Name:(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether
CAS No.:869858-19-5
Molecular Formula:C₃₈H₅₈O₅S
Molecular Weight:626.942
Hs Code.:

Synonyms:(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

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Chemical Property of (25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

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Technology Process of (25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

There total 3 articles about (25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 869858-16-2
23-iodo-24-norchol-5-en-3β-ol

: 96947-45-4
(R)-2-methyl-1-(phenylsulfonyl)-3-(tetrahydropyranyloxy)propane

: 869858-19-5
(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 - -65 ℃; for 0.5h;
DOI:10.1016/j.steroids.2005.02.014

Reference yield:

: 869858-15-1
24-norchol-5-en-3β-23-diol 23-tosylate

: 869858-19-5
(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / KI / acetone / 20 h / Heating

2: 82 percent / iPr₂NLi; HMPA / tetrahydrofuran / 0.5 h / -78 - -65 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1016/j.steroids.2005.02.014

Reference yield:

: 64907-38-6
3β-24-norchol-5-ene-3,23-diol

: 869858-19-5
(25R)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / CHCl₃; pyridine / 48 h / 20 °C

2: 89 percent / KI / acetone / 20 h / Heating

3: 82 percent / iPr₂NLi; HMPA / tetrahydrofuran / 0.5 h / -78 - -65 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; pyridine; chloroform; acetone;
DOI:10.1016/j.steroids.2005.02.014