(2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

Base Information

• Chemical Name: (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)
• CAS No.: 888042-20-4
• Molecular Formula: C₂₃H₂₁ClO₆
• Molecular Weight: 428.869
• Mol file: 888042-20-4.mol

Synonyms:(2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

Chemical Property of (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one)

There total 2 articles about (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione (7634-11-9,5128-41-6) + benzyl bromide (100-39-0) → (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one) (888042-20-4)

Guidance literature:

(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione; With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h;

benzyl bromide; In N,N-dimethyl-formamide; for 24h;

DOI:10.1021/jm801517j

Reference yield:

griseofulvin (126-07-8) → (2S,6'R)-(7-chloro-4-benzyloxy-6-methoxy-benzofuran-3-one)-2-spiro-1'-(2'-methoxy-6'-methyl-cyclohex-2'-en-4'-one) (888042-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; magnesium / diethyl ether; toluene / Sonication

2: silver(l) oxide / 1,4-dioxane

With iodine; magnesium; silver(l) oxide; In 1,4-dioxane; diethyl ether; toluene;

DOI:10.1021/jm200835c

upstream raw materials:

(2S,5’R)-7-chloro-4-hydroxy-3’,6-dimethoxy-5’-methylspiro[benzofuran-2,4’-cyclohex-2-ene]-1',3 -dione

benzyl bromide

griseofulvin