1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)
• CAS No.: 10252-94-5
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Mol file: 10252-94-5.mol

Synonyms:1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)

Chemical Property of 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)

Chemical Property:

• Melting Point: 144-145 °C
• Boiling Point: 355.7±11.0 °C(Predicted)
• PKA: 6.18±0.20(Predicted)
• PSA: 17.82000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.29090

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-dihydro-6-methyl-1H-Pyrrolo[1,2-a]benzimidazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)

There total 6 articles about 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-pyrrolidinon (616-45-5) + 1-chloro-4-methyl-2-nitro-benzene (89-60-1) → 6-Methyl-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazol (10252-94-5)

Guidance literature:

2-pyrrolidinon; 1-chloro-4-methyl-2-nitro-benzene; With potassium phosphate; copper(l) iodide; N-methyl-ethane-1,2-diamine; In toluene; at 100 ℃; for 18h;

With water; In toluene;

With iron; sodium hydrogencarbonate; acetic acid; more than 3 stages; Product distribution / selectivity;

Reference yield: 86.0%

2-pyrrolidinon (616-45-5) + 3-chloro-2-nitrotoluene (5367-26-0) → 6-Methyl-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazol (10252-94-5)

Guidance literature:

2-pyrrolidinon; 3-chloro-2-nitrotoluene; With caesium carbonate; palladium(II) trifluoroacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 ℃; for 18h;

With iron; acetic acid; In toluene; for 0.5h; Heating / reflux;

With sodium hydrogencarbonate; In water; Product distribution / selectivity;

Reference yield: 81.0%

5-methyl-2-(pyrrolidin-1-yl)aniline (91429-70-8) → 6-Methyl-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazol (10252-94-5)

Guidance literature:

With dihydrogen peroxide; In water; ethyl acetate; for 0.666667h; Reflux; Green chemistry;

DOI:10.1016/j.tetlet.2017.07.102

upstream raw materials:

2-pyrrolidinon

1-chloro-4-methyl-2-nitro-benzene

3-chloro-2-nitrotoluene

2-cyclopropyl-5-methyl-1H-benzimidazole