N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

Base Information

• Chemical Name: N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide
• CAS No.: 518036-99-2
• Molecular Formula: C₂₆H₃₃N₅O₄
• Molecular Weight: 479.579

Synonyms:N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

Chemical Property of N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

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Technology Process of N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

There total 2 articles about N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine (138609-27-5) + 3,4-dimethoxybenzylzinc chloride → N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide (518036-99-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; Heating;

DOI:10.1016/S0968-0896(02)00325-5

Reference yield:

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine (152941-69-0) → N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide (518036-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Heating

2: 58 percent / [1,1'-bis(PPh₂)ferrocene]dichloropalladium(II)*CHCl₃ / tetrahydrofuran / Heating

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00325-5

Reference yield: 31.0%

N-[6-(3,4-dimethoxy-benzyl)-2-(2,2-dimethyl-propionylamino)-pyrido[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide (518036-99-2) → 6-(3,4-dimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4-diamine

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 120h;

DOI:10.1016/S0968-0896(02)00325-5

upstream raw materials:

2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine

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