6-Acetyl-7-methyl-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 6-Acetyl-7-methyl-1,2,3,4-tetrahydronaphthalene
• CAS No.: 10188-69-9
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.269
• Hs Code.: 2914399090
• DSSTox Substance ID: DTXSID40511084
• Nikkaji Number: J268.440C
• Wikidata: Q82369697
• Mol file: 10188-69-9.mol

Synonyms:6-ACETYL-7-METHYL-1,2,3,4-TETRAHYDRONAPHTHALENE;10188-69-9;1-(3-METHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHANONE;1-(3-Methyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one;DTXSID40511084;AKOS006276992;J-000508

Chemical Property of 6-Acetyl-7-methyl-1,2,3,4-tetrahydronaphthalene

Chemical Property:

• PSA: 17.07000
• LogP: 3.07640
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 188.120115130
• Heavy Atom Count: 14
• Complexity: 221

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-ACETYL-7-METHYL-1,2,3,4-TETRAHYDRONAPHTHALENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(CCCC2)C=C1C(=O)C

Technology Process of 6-Acetyl-7-methyl-1,2,3,4-tetrahydronaphthalene

There total 6 articles about 6-Acetyl-7-methyl-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

6-methyl-1,2,3,4-tetrahydronaphthalene (1680-51-9) + acetyl chloride (75-36-5) → 1-(2-methyl-5,6,7,8-tetrahydro-[1]naphthyl)-ethanone (97023-04-6) + acetyl-3 methyl-2 tetrahydro-5,6,7,8 naphtalene (10188-69-9) + 1-(3-Methyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-ethanone

Guidance literature:

aluminium trichloride; In 1,2-dichloro-ethane; at 26 ℃; for 3h; Product distribution; other solvent;

Reference yield:

acetic anhydride (108-24-7) → acetyl-3 methyl-2 tetrahydro-5,6,7,8 naphtalene (10188-69-9)

Guidance literature:

With aluminium trichloride; nitrobenzene; at 0 ℃;

DOI:10.1021/ja01186a065

Reference yield:

6-methyl-1,2,3,4-tetrahydronaphthalene (1680-51-9) + acetyl chloride (75-36-5) → acetyl-3 methyl-2 tetrahydro-5,6,7,8 naphtalene (10188-69-9)

Guidance literature:

upstream raw materials:

6-methyl-1,2,3,4-tetrahydronaphthalene

acetyl chloride

acetic anhydride

7-methyl-3,4-dihydro-2H-naphthalen-1-one