2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester

Base Information

• Chemical Name: 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester
• CAS No.: 436864-59-4
• Molecular Formula: C₄₂H₃₈N₂O₈
• Molecular Weight: 698.772
• Mol file: 436864-59-4.mol

Synonyms:2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester

Chemical Property of 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester

There total 6 articles about 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-benzyloxyoxalyl-amino}-benzoic acid benzhydryl ester → 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester (436864-59-4)

Guidance literature:

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; for 2h;

DOI:10.1021/jm034088d

Reference yield:

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid (402924-97-4) → 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester (436864-59-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 62 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

2: copper(II) acetate / dimethylformamide / 6 h / 90 °C

3: 700 mg / N,N-diisopropylethylamine / dimethylformamide / 20 °C

4: 72 percent / acetone / 20 °C

5: 100 percent / Pd(Ph₃P)4; morpholine / CH₂Cl₂ / 2 h

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm034088d

Reference yield:

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid allyl ester (402924-98-5) → 2-{[4-(2-acetylamino-2-carboxyethyl)-2-ethylphenyl]-benzyloxyoxalylamino}-benzoic acid benzhydryl ester (436864-59-4)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(II) acetate / dimethylformamide / 6 h / 90 °C

2: 700 mg / N,N-diisopropylethylamine / dimethylformamide / 20 °C

3: 72 percent / acetone / 20 °C

4: 100 percent / Pd(Ph₃P)4; morpholine / CH₂Cl₂ / 2 h

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm034088d

upstream raw materials:

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid

2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid allyl ester

benzyl (2E)-2-(acetylamino)-3-(4-amino-3-ethylphenyl)-2-propenoate

2-[4-(2-acetylamino-2-allyloxycarbonylethyl)-2-ethylphenylamino]-benzoic acid

Downstream raw materials:

methyl 2-{4-[(N-acetyl-4-[(carboxycarbonyl)(2-carboxyphenyl)amino]-3-ethylphenylalanyl)amino]butoxy}-6-hydroxybenzoate

methyl 2-[(5-{[2-(acetylamino)-3-(4-{2-[(benzhydryloxy)carbonyl][(benzyloxy)(oxo)acetyl]anilino}-3-ethylphenyl)propanoyl]amino}pentyl)oxy]-6-hydroxybenzoate