2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE

Base Information

• Chemical Name: 2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE
• CAS No.: 10150-27-3
• Molecular Formula: C19H18 N P
• Molecular Weight: 291.332
• Hs Code.: 2933399090
• Mol file: 10150-27-3.mol

Synonyms:1-(Diphenylphosphino)-2-(2-pyridyl)ethane;2-[2-(Diphenylphosphino)ethyl]pyridine; Diphenyl(2-(pyridin-2-yl)ethyl)phosphine

Chemical Property of 2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE

Chemical Property:

• Melting Point: 58-62 °C
• Boiling Point: 422.2±28.0 °C(Predicted)
• PKA: 5.56±0.12(Predicted)
• PSA: 26.48000
• LogP: 3.75700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: air sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[2-(Diphenylphosphino)ethyl]pyridine, min. 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE

There total 5 articles about 2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + (tert-butyldimethylsilyl)diphenylphosphine (678187-53-6) → 2-(2-(diphenylphosphino)ethyl)pyridine (10150-27-3)

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2004.10.098

Reference yield: 92.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + diphenylphosphane (829-85-6) → 2-(2-(diphenylphosphino)ethyl)pyridine (10150-27-3)

Guidance literature:

With C₅₆H₇₈N₂O₂Zr; In neat (no solvent); at 25 ℃; for 40h; Schlenk technique;

DOI:10.1021/acs.inorgchem.7b02248

Reference yield:

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + diphenylphosphane (829-85-6) → 2-(2-(diphenylphosphino)ethyl)pyridine (10150-27-3) + Tetraphenyldiphosphin (1101-41-3)

Guidance literature:

With bis(pentamethylcyclopentadienyl)tin dichloride; hydrogen; In benzene-d6; at 65 ℃; for 18h; Reagent/catalyst; Temperature;

DOI:10.1039/c5dt04272k

upstream raw materials:

2-vinylpyridine

diphenylphosphane

(tert-butyldimethylsilyl)diphenylphosphine

pyridine-2-carbaldehyde

Downstream raw materials:

cis[PtPh2( η (1)-(1-(diphenylphosphanyl)-2-(pyrid-2-yl)etane))]

trans-{iridium(1-(2-pyridyl)-2-(diphenylphosphino)ethane)2(CO)Cl}

{iridium(1-(2-pyridyl)-2-(diphenylphosphino)ethane)(CO)Cl}*Et₂O

PdCl(C₆Cl₂F₃)(P(CH₂CH₂C₅H₄N)(C₆H₅)2)

Refernces

• 1、 Novas, Bryan T.,Bange, Christine A.,Waterman, Rory. "Photocatalytic Hydrophosphination of Alkenes and Alkynes Using Diphenylphosphine and Triamidoamine-Supported Zirconium". . p. 1640 - 1643. Retrieved 2019.
• 2、 Uhlig,Maaser. "-". . p. 205,211. Retrieved 1966.
• 3、 Toto, Susan D.,Doi, Joyce Takahashi. "A Functionalized Alkyldiphenylphosphine as an Efficient and Mild Reagent in CCl4-Promoted Substitution Reactions: Kinetics and Mechanism of the Reaction in CHCl3". . p. 4999 - 5003. Retrieved 1987.
• 4、 Nolla-Saltiel, Roberto,Geer, Ana M.,Taylor, Laurence J.,Churchill, Olivia,Davies, E. Stephen,Lewis, William,Blake, Alexander J.,Kays, Deborah L.. "Hydrophosphination of Activated Alkenes by a Cobalt(I) Pincer Complex". supporting information. p. 3148 - 3157. Retrieved 2020/06/08.