4-Pyridinecarboxamide,3-hydroxy-(9CI)

Base Information

• Chemical Name: 4-Pyridinecarboxamide,3-hydroxy-(9CI)
• CAS No.: 10128-73-1
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.125
• Hs Code.: 2933399090
• Mol file: 10128-73-1.mol

Synonyms:3-Hydroxyisonicotinamide;

Chemical Property of 4-Pyridinecarboxamide,3-hydroxy-(9CI)

Chemical Property:

• Melting Point: 201 °C
• Boiling Point: 479.285 °C at 760 mmHg
• Flash Point: 243.663 °C
• PSA: 76.21000
• Density: 1.384 g/cm³
• LogP: 0.58640

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydroxyisonicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Hydroxyisonicotinamide is used as a reactant in the synthesis of furopyridine derivatives as FXa inhibitors.

Technology Process of 4-Pyridinecarboxamide,3-hydroxy-(9CI)

There total 2 articles about 4-Pyridinecarboxamide,3-hydroxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 3-hydroxyisonicotinate (18342-97-7) → 3-hydroxyisonicotinamide (10128-73-1)

Guidance literature:

With ammonia; In methanol; at 120 ℃; for 5h;

Reference yield:

→ 3-hydroxyisonicotinamide (10128-73-1)

Guidance literature:

3-Hydroxy-isonicotinsaeure-methylester, konz. NH4OH; 20grad, 1h;

Reference yield: 58.0%

benzoyl chloride (98-88-4) + 3-hydroxyisonicotinamide (10128-73-1) → 4-cyanopyridin-3-yl benzoate (1446357-60-3)

Guidance literature:

In toluene; at 170 ℃; for 0.25h; Molecular sieve; Microwave irradiation;

DOI:10.1021/ol401516e

upstream raw materials:

ethyl 3-hydroxyisonicotinate

Downstream raw materials:

3-hydroxyisonicotinonitrile

3-benzoyl-pyrido[4,3-e][1,3]oxazine-2,4-dione

3-(3t-phenyl-acryloyl)-pyrido[4,3-e][1,3]oxazine-2,4-dione

3-(4-chloro-benzoyl)-pyrido[4,3-e][1,3]oxazine-2,4-dione

Refernces

• 1、 -. "FUSED FURAN COMPOUND". Page/Page column 132. . Retrieved 2008/06/13.