5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Base Information

Chemical Name:5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol
CAS No.:1239963-77-9
Molecular Formula:C₁₈H₁₅Cl₂FN₂S
Molecular Weight:381.301
Hs Code.:

Synonyms:5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Suppliers and Price of 5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Chemical Property:

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Technology Process of 5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

There total 8 articles about 5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-76-8
1-amino-3-(3,4-dichlorophenyl)-3-methylbutan-2-one hydrobromide

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1239963-77-9
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: With triethylamine; In benzene; for 6h; Reflux;

Reference yield:

: C₁₈H₁₇Cl₂FN₂OS

: 1239963-77-9
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: With acetic acid; for 5h; Reflux;

Reference yield:

: 2-(3,4-dichlorophenyl)-2-methylpropanenitrile

: 1239963-77-9
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: diethyl ether / 3 h / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 24 h

5.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

5.2: 2 h / Reflux

6.1: triethylamine / benzene / 6 h / Reflux

With tetra-n-butylammonium tribromide; oxalyl dichloride; hexamethylenetetramine; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; toluene; benzene;