2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Base Information

Chemical Name:2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
CAS No.:1239956-60-5
Molecular Formula:C₂₅H₁₉Cl₃F₂N₂S
Molecular Weight:523.861
Hs Code.:

Synonyms:2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Chemical Property of 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Technology Process of 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

There total 1 articles about 2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1239963-77-9
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

: 55117-15-2
2-chloro-6 fluorobenzyl chloride

: 1239956-60-5
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: With potassium carbonate; In acetone; for 2h;

Reference yield: 89.0%

: 1239956-60-5
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-34-6
4-bromo-2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: With bromine; sodium carbonate; In dichloromethane; water; at 0 ℃;

Reference yield:

: 1239956-60-5
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-35-7
2-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-4-phenyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium carbonate / dichloromethane; water / 0 °C

2: potassium phosphate / tris(o-methoxyphenyl)phosphine; palladium diacetate / ethanol; water / Reflux

With potassium phosphate; bromine; sodium carbonate; tris(o-methoxyphenyl)phosphine; palladium diacetate; In ethanol; dichloromethane; water; 2: Suzuki Coupling;